解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Recent suggestions that the rat prostate is an alymphatic, immunologically privileged site stimulated further investigation of its status using a variety of techniques. Fixation of certain organs by vascular perfusion of glutaraldehyde followed by plastic embedding avoids the distortion and stromal reorganization that...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197902000-00011
更新日期:1979-02-01 00:00:00
abstract::Monocytes play a crucial role in the response of lymphocytes to phytomitogens. This role is evident during the very early events after exposure to the mitogen. Thus, significant lymphocyte transformation does occur when monocytes are removed from the culture within a few hours after exposure to mitogen, and the presen...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197901000-00015
更新日期:1979-01-01 00:00:00
abstract::The case studies of four patients with post-transplantation calcinosis are presented. Three of the four patients died of inanition and sepsis secondary to infection of extensive soft tissue ulcers and diffuse cutaneous vascular calcification with gangrene. The fourth patient survived following removal of all four para...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197901000-00006
更新日期:1979-01-01 00:00:00
abstract::Ontogenic development of suppressor cells was studied in mouse embryos. It was found that liver cells of embryos at various stages of gestation were capable of interfering with the mixed leukocyte culture (MLC) reaction. The MLC reaction was also inhibited by embryonic spleen and thymus cells. However, the latter were...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197812000-00016
更新日期:1978-12-01 00:00:00
abstract::Blocking activity of mouse pregnancy serum was investigated using a well defined one-way mixed lymphocyte culture and a cell-mediated microcytotoxicity test. Allogeneic (C57BL (H-2b) X CBA/Ca (H-2k)) and syngeneic (C57BL (H-2b) X C57BL (H-2b)) pregnancy and postpartum sera were found to stimulate rather than inhibit t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197811000-00002
更新日期:1978-11-01 00:00:00
abstract::The question has not been previously investigated as to whether host lymphocytes infiltrate vascularized organ allografts in indiscriminate fashion, or whether they are retained selectively because of specific antigenic recognition sites on their surfaces. By using a dual cardiac allograft model in LEW rats, we have e...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197809000-00011
更新日期:1978-09-01 00:00:00
abstract::This study investigates the possibility that the active enhancing properties of bone marrow (BM) cells may be related to Ia-like determinants on their surface membranes. Less chromium was released on a cell per cell basis from nucleated baboon BM cells used as targets in complement-dependent cytotoxicity than from lab...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197808000-00001
更新日期:1978-08-01 00:00:00
abstract::A quantitative absorption-blocking assay was used to measure the levels of antibody in immune rabbit sera that react with the serologically defined HLA molecular complex on the cell surface. Quantitation was determined by comparing the number of xenoantibody-treated cells with the number of untreated control cells nee...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197807010-00009
更新日期:1978-07-01 00:00:00
abstract::Comparative experiments were performed on 41 allogenic rat kidney transplants to determine the mitotic behaviour and proliferative metabolism (application of 3H-thymidine) in the first 6 days after recirculation. Three days after transplantation, DNA synthesis in the tubular epithelial cells of the cortex and the medu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197807010-00003
更新日期:1978-07-01 00:00:00
abstract::Unilateral, intraorganal injection of parental lymph node cells into thyroid lobes of F1 hybrid rats elicited an intense, local graft-versus-host reaction within the injected lobes containing massive numbers of lymphocytes. Surprisingly, significant mononuclear cell infiltration was also seen within the contralateral ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197805000-00003
更新日期:1978-05-01 00:00:00
abstract::H-1-incompatible rat renal allograft survival rates are strongly influenced by the non-major histocompatibility system (MHS) genes. The same H-1 (MHS) incompatibility tested on four different non-MHS backgrounds gave widely differing results ranging from 11 to 60% fractional survival between the best and the poorest (...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197805000-00006
更新日期:1978-05-01 00:00:00
abstract::In 33 renal allograft recipient-donor pairs, B and T lymphocyte complement-dependent cytotoxicity crossmatches and mixed lymphocyte culture (MLC) blocking experiments were performed and the results were correlated with graft outcome. MLC blocking particularly in the unidirectional culture against donor-stimulating cel...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197804000-00002
更新日期:1978-04-01 00:00:00
abstract::Spleen cells obtained from C57BL/Ks (Ks, H-2d) mice carrying passively enhanced Sarcoma I (Sa I, H-2a) tumors were tested for alloantibody formation, lymphocyte blastogenesis, antibody-dependent cellular cytotoxicity, and cell to cell cytotoxicity. Assays were usually performed approximately 6 weeks after tumor inocul...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197803000-00011
更新日期:1978-03-01 00:00:00
abstract::Heterologous anti-immunoglobulin is a potent immunosuppressive agent that prolongs H-2- and H-3-incompatible skin graft survival. In conjunction with antithymocyte serum, anti-immunoglobulin promotes greater graft life than either antiserum used alone, without evidence of toxicity to recipient animals. Combination tre...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197711000-00007
更新日期:1977-11-01 00:00:00
abstract::A study was designed to assess the cellular immune competence of Lewis rats with streptozotocin-induced diabetes. First-set Fischer skin allografts were rejected in 10.9 days by nondiabetic Lewis recipients and in 12.0 days by diabetic Lewis recipients. Second-set skin allografts in the same strain combination, utiliz...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197711000-00008
更新日期:1977-11-01 00:00:00
abstract::Acute antibody-mediated rejection (AAR) of mouse skin allografts was studied in nine donor-recipient combinations with increasing histoincompatibility ranging from an H-Y to a complete H-2 plus on-H-2 disparity. AAR was induced by the injection of specific alloantiserum along with a heterologous complement on day 7 af...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197709000-00002
更新日期:1977-09-01 00:00:00
abstract::Histoincompatibility was analyzed to describe as precisely as possible the sequence of gross morphological events taking place during allograft rejection among closely related conspecifics from a natural population of the bisexual lizard Cnemidophorus tigris. Two types of rejection were noted, depending on whether the...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197708000-00006
更新日期:1977-08-01 00:00:00
abstract::When normal mice are exposed for short periods to ultraviolet light (UV), they support the progressive growth of transplanted syngeneic UV-induced tumors. Normal nonirradiated mice almost always reject these tumor implants. The UV-mediated suppression of the antitumor response can be adoptively transferred to normal s...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197708000-00005
更新日期:1977-08-01 00:00:00
abstract::Using antisera to human beta2-microglobulin and an immunofluorescent technique, beta2-microglobulin was found to be localized along tubular and glomerular basement membranes of renal bipsies studied. Since beta2-microglobulin is a subunit of HLA preparations, it may also serve as an indirect marker for the presence of...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197707000-00001
更新日期:1977-07-01 00:00:00
abstract::Seventy-two dog kidneys were stored under hypothermia as described by Collins and Sacks between 24 and 72 hr and then transplanted. The immediate function of the kidneys was measured by p-aminohippuric acid and inulin clearances. Twenty-four hr proved to be the maximum safe preservation time with both methods. The imm...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197705000-00009
更新日期:1977-05-01 00:00:00
abstract::The effect of the tritiated thymidine (3H-TdR) suicide technique on the ability of donor cells to induce fatal graft-versus-host disease (GVHD) was studied. C57BL/6 (H-2b) spleen cells were stimulated in vitro with irradiated BALB/c (H-2d) Moloney lymphoma cells in mixed culture and 3H-TdR of high-specific activity ad...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197704000-00001
更新日期:1977-04-01 00:00:00
abstract::Rabbit antisera to rat thoracic duct lymphocytes were examined by absorption analysis with quantitative radioimmunoassays to determine the tissue distribution of the antigens recognised and the amount of antibody against different specificities. Seven of eight sera were remarkably specific for leucocytes and one serum...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197704000-00009
更新日期:1977-04-01 00:00:00
abstract::The majority of skin tumors induced in mice by ultraviolet (UV) light are rejected when implanted into normal syngeneic recipients. Subcarcinogenic levels of UV light exposure render the normally resistant mice susceptible to tumor challenge. The immunoregulatory effect of UV light appears to be additive, since the gr...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197704000-00008
更新日期:1977-04-01 00:00:00
abstract::Agarose is known to inhibit nonspecifically the cytotoxic effects of normal sera on xenogeneic lymphoid cells. To find an explanation for this agarose effect we have studied its requirements using guinea pig and human sera as the source of activity and rat thymocytes as target cells. Control assays were performed usin...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197704000-00007
更新日期:1977-04-01 00:00:00
abstract::Three strains of miniature swine, each homozygous for a different allele of the major histocompatibility locus (MHC), have been developed by a selective breeding scheme based on tissue typing of the offspring of each generation. Prior to breeding, the original parents were reciprocally immunized by skin grafts and lym...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197612000-00004
更新日期:1976-12-01 00:00:00
abstract::The levels of HLA-A and -B antigens expressed by placenta have been assessed relative to parental and other A and B antigen types that were not shared by the foetus. A purified preparation of placenta plasma membrane was used to estimate the antigen activities. The results indicate that maternally and paternally inher...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197612000-00009
更新日期:1976-12-01 00:00:00
abstract::The aim of our study was to sensitize cells in vitro, follow their proliferative and cytotoxic responses, and determine their ability to cause lethal graft-versus-host disease (GVHD). C57BL/6 (H2b) spleen cells were incubated with irradiated BALB/C (H2d) Moloney lymphoma cells (LSTRA) in mixed leukocyte culture condit...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197612000-00008
更新日期:1976-12-01 00:00:00
abstract::Retrospective mixed leukocyte culture studies were performed in eight patients who had either rejected their marrow grafts or experienced graft-versus-host disease and in seven patients with successful marrow engraftment. In tests of pre-and post-transplant lymphocytes we found no evidence that rejection or graft-vers...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197611000-00010
更新日期:1976-11-01 00:00:00
abstract::A technique of orthotopic renal transplantation in rabbits is described. The technique has been evolved in an experience of over 400 grafts, and difficulties encountered in producing satisfactory anaesthesia and techniques of anastomosis and in obtaining reliable graft function postoperatively have been defined and ov...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197611000-00003
更新日期:1976-11-01 00:00:00
abstract::Heterologous anti-immunoglobulin (AI) is a potent immunosuppressive agent which compares favorably to anti-thymocyte serum (ATS) in inhibiting E and EAC-rosette formation and diminishing the secondary antibody response to sheep erythrocytes and E. coli lipopolysaccharide. AI prolongs H-2 incompatible skin allograft su...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197609000-00003
更新日期:1976-09-01 00:00:00
abstract::A sensitive micromethod for generating and assaying allogeneically induced cytotoxic human lymphocytes in vitro is described. Responding lymphocytes are cultured with mitomycin-C treated allogeneic stimulating cells in wells of replicate microtrays for both one-way mixed leukocyte culture (MLC) and cell-mediated lymph...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197606000-00005
更新日期:1976-06-01 00:00:00
abstract::Treatment of BN recipients with soluble WAG/Rij histocompatibility antigens (HCA) did not produce prolongation of (WAG/Rij X BN) F1 heart allografts but resulted in specific sensitization of the recipients in most cases. Three different anti-WAG/Rij sera (ADS) were tested, either alone or complexed in equivalence to 0...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197606000-00003
更新日期:1976-06-01 00:00:00
abstract::Two infants born to mothers who had been given a renal transplant and who were receiving azathioprine and prednisone have been followed up for over 2 years. Initially both had lower than normal lymphocyte counts and cortisol levels. Chromosomal aberrations similar to those found in the lymphocytes of the mothers were ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197604000-00004
更新日期:1976-04-01 00:00:00
abstract::As a first step in the study of the possible relationship between the T/t and H-2 complexes, the H-2 antigenic composition of the strains carrying factors t12, tw32, tw2, tw8, t1, t0, t6, tw1, tw71, tw73, tw12, tw5, tw75, and t38 was studied by using a battery of antisera containing antibodies against inbred-derived H...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197603000-00004
更新日期:1976-03-01 00:00:00
abstract::Murine lymphoid cells sensitized against allografts express two types of cytotoxicity measured in vitro in short-term assays of 2 to 3 hr by 51Cr release. One type of cytotoxicity is specific against target cells carrying the sensitizing alloantigens, and the other type is nonspecific against both syngeneic and unrela...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197602000-00002
更新日期:1976-02-01 00:00:00
abstract::Sera were obtained from 48 gravida II prenatal and 211 multiparous nonpregnant females and examined for leukocyte antibodies comparing a standard lymphocytotoxicity (CY) test with capillary agglutination (CA). Antibody was detected in 41% of the samples in both groups but only CA tests were positive with approximately...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197602000-00001
更新日期:1976-02-01 00:00:00
abstract::Monocytes from human peripheral blood, when incubated in vitro, spread onto the surface of the glass. Horse antihuman lymphocyte globulin (ALG) added to the incubation chamber inhibits the spreading, while normal horse globulin (NHG) does not. The inhibition depends on the concentration of ALG admixed to the mononucle...
journal_title:Transplantation
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::Teratoma 402 AX is an embryo-like tumor cell line originally derived from the testicles of strain 129/J mice. This teratocarcinoma grows well in males and pregnant females but poorly in virgin females when given in small doses. Induction of growth of this tumor is syngeneic and allogeneic virgin females was achieved b...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197510000-00005
更新日期:1975-10-01 00:00:00
abstract::The ability of concanavalin-A (Con-A) to activate lymphocytes to secrete human lymphotoxin (LT) was tested in the presence of agents known to modify the intracellular levels of cyclic nucleotides (cAMP and cGMP). Lymphocytes were treated with these agents at different stages of activation: (1) during the first encount...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197510000-00010
更新日期:1975-10-01 00:00:00
abstract::A rapid microcytotoxicity assay for the detection of HL-A antigens on tissue culture cells derived from human solid tumors is described. Tumor cells were prelabeled with 125Iododeoxyuridine. Isotopically labeled tumor cells were reacted with up to 37 highly selected HL-A antisera and diluted rabbit complement. Results...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/00007890-197509000-00005
更新日期:1975-09-01 00:00:00